Pyrvinium Iodide

Chemical Structure : Pyrvinium Iodide

CAS No.: 35648-29-4

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货号: PC-60384Not For Human Use, Lab Use Only.

Pyrvinium Iodide is an anthelmintic effective for pinworms that shows to be a potent inhibitor of Wnt signaling with EC50 of 10 nM, binds to all CK1 family members in vitro at low nanomolar concentrations and selectively potentiates CK1α kinase activity.

规格	价格	库存
25 mg	￥580	In stock
50 mg	￥880	In stock
100 mg	￥1280	In stock
250 mg		Get quote

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生物&药学活性

Pyrvinium Iodide is an anthelmintic effective for pinworms that shows to be a potent inhibitor of Wnt signaling with EC50 of 10 nM, binds to all CK1 family members in vitro at low nanomolar concentrations and selectively potentiates CK1α kinase activity.
Pyrvinium Iodide inhibits Wnt signaling downstream of β-catenin, and promotes Pygopus degradation.
Pyrvinium Iodide also is a potent inhibitor of HH signaling by reducing the stability of the Gli family of transcription factors.

物理化学性质&存储条件

分子量	509.435
分子式	C26H28IN3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[(E)-2-(2,5-dimethyl-1-phenylpyrrol-3-yl)ethenyl]-N,N,1-trimethylquinolin-1-ium-6-amine iodide

参考文献

1. Thorne CA, et al. Nat Chem Biol. 2010 Nov;6(11):829-36.