Pyrvinium Iodide |CAS:35648-29-4 Probechem Biochemicals

Chemical Structure : Pyrvinium Iodide

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Pyrvinium Iodide

货号: PC-60384Not For Human Use, Lab Use Only.

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生物&药学活性

An anthelmintic effective for pinworms that shows to be a potent inhibitor of Wnt signaling with EC50 of 10 nM, binds to all CK1 family members in vitro at low nanomolar concentrations and selectively potentiates CK1α kinase activity; inhibits Wnt signaling downstream of β-catenin, and promotes Pygopus degradation; also is a potent inhibitor of HH signaling by reducing the stability of the Gli family of transcription factors.

物理化学性质&存储条件

分子量	509.435
分子式	C26H28IN3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[(E)-2-(2,5-dimethyl-1-phenylpyrrol-3-yl)ethenyl]-N,N,1-trimethylquinolin-1-ium-6-amine iodide

参考文献

1. Thorne CA, et al. Nat Chem Biol. 2010 Nov;6(11):829-36.