Pyrvinium |CAS:7187-62-4 Probechem Biochemicals

Chemical Structure : Pyrvinium

CAS No.: 7187-62-4

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Pyrvinium (Viprynium)

货号: PC-60383Not For Human Use, Lab Use Only.

Pyrvinium is an anthelmintic effective agent for pinworms that shows to be a potent inhibitor of Wnt signaling with EC50 of 10 nM, binds to all CK1 family members in vitro at low nanomolar concentrations and selectively potentiates CK1α kinase activity.

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100 mg	￥1280	In stock
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生物&药学活性

Pyrvinium is an anthelmintic effective agent for pinworms that shows to be a potent inhibitor of Wnt signaling with EC50 of 10 nM, binds to all CK1 family members in vitro at low nanomolar concentrations and selectively potentiates CK1α kinase activity.
Pyrvinium inhibits Wnt signaling downstream of β-catenin, and promotes Pygopus degradation.
Pyrvinium also is a potent inhibitor of HH signaling by reducing the stability of the Gli family of transcription factors.

物理化学性质&存储条件

分子量	382.52
分子式	C26H28N3+
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[(E)-2-(2,5-dimethyl-1-phenylpyrrol-3-yl)ethenyl]-N,N,1-trimethylquinolin-1-ium-6-amine

参考文献

1. Thorne CA, et al. Nat Chem Biol. 2010 Nov;6(11):829-36.

2. Li B, et al. Cancer Res. 2014 Sep 1;74(17):4811-21.

3. Li B, et al. Sci Signal. 2017 Jun 27;10(485). pii: eaak9916.

Pyrvinium (Viprynium)

生物&药学活性

物理化学性质&存储条件

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Pyrvinium (Viprynium)

生物&药学活性

物理化学性质&存储条件

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