Pyronaridine

Chemical Structure : Pyronaridine

CAS No.: 74847-35-1

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货号: PC-72957Not For Human Use, Lab Use Only.

Pyronaridine is a fast-acting (chloroquine-like) drug that has the demonstrated ability to inhibit P. falciparum β-hematin formation in vitro, suppress the selection of M5717-resistant mutants.

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生物&药学活性

Pyronaridine is a fast-acting (chloroquine-like) drug that has the demonstrated ability to inhibit P. falciparum β-hematin formation in vitro, suppress the selection of M5717-resistant mutants.

物理化学性质&存储条件

分子量	518.058
分子式	C29H32ClN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino)-2,6-bis(pyrrolidin-1-ylmethyl)phenol

参考文献

1. Arez F, et al. ACS Infect Dis. 2019 Nov 8;5(11):1831-1842.

2. Rottmann M, et al. Antimicrob Agents Chemother. 2020 Mar 24;64(4):e02181-19.

Pyronaridine

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