Purfalcamine |CAS:1038620-68-6 Probechem Biochemicals

Chemical Structure : Purfalcamine

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Purfalcamine

货号: PC-62162Not For Human Use, Lab Use Only.

Purfalcamine is a potent, specific inhibitor of Plaasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) with IC50 of 17 nM.

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生物&药学活性

Purfalcamine is a potent, specific inhibitor of Plaasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) with IC50 of 17 nM; inhibits proliferation of P falciparum strains (Dd2, FCB, HB3 and W2) with nanomolar EC50s of (171–259 nM); blocks microneme discharge and erythrocyte invasion by P. falciparum merozoites; an anti-malaria parasite agent.

物理化学性质&存储条件

分子量	528.636
分子式	C29H33FN8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	[4-[[2-[(4-aminocyclohexyl)amino]-9-(3-fluorophenyl)purin-6-yl]amino]phenyl]-piperidin-1-ylmethanone

参考文献

1. Kato N, et al. Nat Chem Biol. 2008 Jun;4(6):347-56.

2. Bansal A, et al. J Biol Chem. 2013 Jan 18;288(3):1590-602.

3. Gaji RY, et al. Antimicrob Agents Chemother. 2014 May;58(5):2598-607.

Purfalcamine

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物理化学性质&存储条件

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Purfalcamine

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