Phox-I1 | p67phox-Rac1 inhibitor | Probechem Biochemicals

Chemical Structure : Phox-I1

CAS No.: 1388151-90-3

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Phox-I1 (p67phox-Rac1 inhibitor)

货号: PC-62448Not For Human Use, Lab Use Only.

Phox-I1 is a specific small molecule inhibitor of Rac1-p67phox interaction, binds to the Rac1 interactive site of p67phox specifically (Ki=100 nM) and interferes with Rac1-GTP interaction with p67phox.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
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100 mg		Get quote

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生物&药学活性

Phox-I1 is a specific small molecule inhibitor of Rac1-p67phox interaction, binds to the Rac1 interactive site of p67phox specifically (Ki=100 nM) and interferes with Rac1-GTP interaction with p67phox.

Phox-I1 is active in suppressing ROS production in both human and murine neutrophils.

Phox-I1 is effective in inhibiting NOX2-mediated superoxide production dose-dependently in human and murine neutrophils without detectable toxicity.

Phox-I1 inhibitedcollagen-induced platelet aggregation without affecting the tail bleeding time, inhibited in vivo platelet adhesion/accumulation at the laser injury sites on the saphenous vein without affecting the time for complete cessation of blood loss.

物理化学性质&存储条件

分子量	401.422
分子式	C23H19N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9-methoxy-5-(3-nitrophenyl)-2-phenyl-5,10b-dihydro-1H-pyrazolo[1,5-c][1,3]benzoxazine

参考文献

1. Bosco EE, et al. Chem Biol. 2012 Feb 24;19(2):228-42.

Phox-I1 (p67phox-Rac1 inhibitor)

生物&药学活性

物理化学性质&存储条件

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Phox-I1 (p67phox-Rac1 inhibitor)

生物&药学活性

物理化学性质&存储条件

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