PfKRS1 inhibitor 30

Chemical Structure : PfKRS1 inhibitor 30

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货号: PC-27033Not For Human Use, Lab Use Only.

PfKRS1 inhibitor 30 is a potent selective inhibitor of P. falciparum lysyl-tRNA synthetase (PfKRS1) with pIC50 of 6.9, >1,000-fold selectivity for PfKRS1 over the human enzyme, exhibits potency against Pfalciparum (3D7) asexual blood stage with EC50 of 6 nM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

物理化学性质&存储条件

分子量	534.55
分子式	C24H32F6N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(((1R,3S)-1-(2-(1,7-diazaspiro[3.5]nonan-7-yl)ethyl)-3-(trifluoromethyl)cyclohexyl)methyl)-2-amino-4-(trifluoromethyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-5-one

参考文献

1. Forte B, et al. J Med Chem. 2026 Jun 2. doi: 10.1021/acs.jmedchem.6c00823.