PfCLK3 inhibitor 4 | PfCLK3 inhibitor | Probechem Biochemicals

Chemical Structure : PfCLK3 inhibitor 4

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PfCLK3 inhibitor 4 (PfCLK3 covalent inhibitor)

货号: PC-23277Not For Human Use, Lab Use Only.

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生物&药学活性

PfCLK3 inhibitor 4 is a potent, covalent inhibitor of Plasmodium falciparum CLK3 kinase (PfCLK3) with pIC50 of 8.02, covalently targets of PfCLK3 cys368, exhibits parasiticidal activity in P. falciparum 3D7 cell line with pEC50 of 7.1.
PfCLK3 inhibitor 4 shows excellent selectivity profile compared to TCMDC-135051.
PfCLK3 inhibitor 4 demonstrates constant activity against different stages of asexual P. falciparum parasites, compared with Artemisinin.
PfCLK3 inhibitor 4 arrests development and kills parasites at every stage in the erythrocytic life cycle.

物理化学性质&存储条件

分子量	519.00
分子式	C28H27ClN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[2-(5-{[4-(2-Chloroacetyl)piperazin-1-yl]methyl}-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzoic Acid

参考文献

1. Brettell SB, et al. J Med Chem. 2024 Oct 23. doi: 10.1021/acs.jmedchem.4c01300.

PfCLK3 inhibitor 4 (PfCLK3 covalent inhibitor)

生物&药学活性

物理化学性质&存储条件

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PfCLK3 inhibitor 4 (PfCLK3 covalent inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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