PTX-BD10-2 | TrkB/C agonist | Probechem Biochemicals

Chemical Structure : PTX-BD10-2

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PTX-BD10-2 (BD10-2)

货号: PC-21241Not For Human Use, Lab Use Only.

PTX-BD10-2 (BD10-2) is a selective, brain-penetrant small molecule TrkB/C receptor partial agonist, shows survival-promoting activity.

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生物&药学活性

PTX-BD10-2 (BD10-2) is a selective, brain-penetrant small molecule TrkB/C receptor partial agonist, shows survival-promoting activity.
PTX-BD10-2 (BD10-2) promotes survival of 3T3-TrkB and 3T3-TrkC cells in a dose-dependent manner, but has no effect on survival of TrkA- or p75-expressing 3T3 cells.
PTX-BD10-2 (BD10-2) reverses cholinergic neuron atrophy associated with pathological tau (AT8 antibody) in late-stage APPL/S mice.
PTX-BD10-2 (BD10-2) prevents aberrant AKT, CaMKII, and GLUA1 phosphorylation, and enhances activity-dependent recruitment of synaptic proteins.
PTX-BD10-2 (BD10-2) significantly reduces memory and LTP impairments, as well as synaptic- and neurotrophin-related signaling deficits in APPL/S mice.
PTX-BD10-2 (BD10-2) also has potentially favorable effects on LTP-dependent complement pathway and synaptic gene transcription.

物理化学性质&存储条件

分子量	444.62
分子式	C26H40N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,4'-(ethane-1,1-diyl)bis(N,N-bis(2-methoxyethyl)aniline)

PTX-BD10-2 (BD10-2)

生物&药学活性

物理化学性质&存储条件

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PTX-BD10-2 (BD10-2)

生物&药学活性

物理化学性质&存储条件

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