PTD10 | BTK PROTAC | Probechem Biochemicals

Chemical Structure : PTD10

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PTD10 (BTK PROTAC PTD10)

货号: PC-20816Not For Human Use, Lab Use Only.

PTD10 is a highly potent BTK PROTAC degrader with DC50 of 0.5 nM in TMD8 cells, inhibits cell growth and induces apoptosis more potently than parent molecule GDC-0853.

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1 g		Get quote

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生物&药学活性

PTD10 is a highly potent BTK PROTAC degrader with DC50 of 0.5 nM in TMD8 cells, inhibits cell growth and induces apoptosis more potently than parent molecule GDC-0853.

物理化学性质&存储条件

分子量	922.02
分子式	C49H51N11O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCC(N4C[C@H](C)N(C5=CC=C(NC6=CC(C7=C(CO)C(N8C(C(N9CC8)=CC%10=C9CC(C)(C)C%10)=O)=NC=C7)=CN(C)C6=O)N=C5)CC4)=O)=O

参考文献

1. Yi-Qian Li, et al. J Med Chem. 2023 May 17. doi: 10.1021/acs.jmedchem.3c00176.

PTD10 (BTK PROTAC PTD10)

生物&药学活性

物理化学性质&存储条件

参考文献

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PTD10 (BTK PROTAC PTD10)

生物&药学活性

物理化学性质&存储条件

参考文献

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