PT-129 | G3BP1/2 PROTAC | Probechem Biochemicals

Chemical Structure : PT-129

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PT-129 (PT129)

货号: PC-23715Not For Human Use, Lab Use Only.

PT-129 is the first potent, selective, and efficacious G3BP1/2 PROTAC degrader, induces degradation of G3BP1 and G3BP2 with DC50 of 5 and 10 μM respectively in L929 cells, Dmax=95%.

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

PT-129 is the first potent, selective, and efficacious G3BP1/2 PROTAC degrader, induces degradation of G3BP1 and G3BP2 with DC50 of 5 and 10 μM respectively in L929 cells, Dmax=95%.
PT-129 also reduces G3BP1 levels in other cell lines, including NIH3T3, A549 and KGN cells, with similar DC50 values.
PT-129 (10 uM) inhibits stress granules (SGs) formation by degrading G3BP1 and G3BP2, promoted SG dissolution.
PT-129 downregulates G3BP-associated transcriptome and proteome.
PT-129 inhibits cancer-associated fibroblasts (CAFs) mediated cancer growth and metastasis, inhibits CAF-fostered ATF4 expression and tumor malignancy.
PT-129 suppressed ATF4 intercellular communication in a migracytosis dependent manner.

物理化学性质&存储条件

分子量	936.99
分子式	C46H48N8O12S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-2-((2-(1H-indazol-1-yl)-2-oxoethyl)sulfonamido)-N-(4-(3-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)propanamido)phenyl)-3-phenylpropanamide

参考文献

1. Dong T, et al. J Am Chem Soc. 2024 Dec 22.

PT-129 (PT129)

生物&药学活性

物理化学性质&存储条件

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PT-129 (PT129)

生物&药学活性

物理化学性质&存储条件

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