PSF inhibitor No. C-30

Chemical Structure : PSF inhibitor No. C-30

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货号: PC-23569Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

PSF inhibitor No. 10-3 is a small molecule inhibitor of RNA-binding protein PTB-associated splicing factor (PSF), effectively inhibits PSF-lncRNA interaction and inhibits PSF target gene expression at the mRNA level.
PSF inhibitor No. 10-3 inhibits the PSF-mediated RNA splicing and the epigenetic pathway that promotes apoptosis and inhibits cell cycle in both breast and prostate cancer cells.
PSF inhibitor No. 10-3 potently inhibits the interaction of PSF with CTBP1-AS probe with IC50 of 2.2 pM.
PSF inhibitor No. 10-3 effectively induces apoptosis in these treatment-resistant cancer cells, inhibits prostate cancer cell proliferation (IC50 = 1.2 μmol/L, 22Rv1 cells).
PSF inhibitor No. 10-3 blocks the process of transcribed RNA to be spliced into mRNA.
PSF inhibitor No. 10-3 (5 mg/kg, five times per week) exhibits tumor growth inhibition in xenograft models of AR-positive 22Rv1 cells with no significant toxic effect, shows remarkably enhanced histone acetylation and cleaved PARP.
PSF functions as an epigenetic modifier by interacting with long noncoding RNAs and the corepressor complex. PSF also promotes RNA splicing events to enhance oncogenic signals.

物理化学性质&存储条件

分子量	284.27
分子式	C16H12O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7,8-dihydroxy-4-(4-methoxyphenyl)chromen-2-one

参考文献

1. Takayama KI, et al. Cancer Res. 2021 Jul 1;81(13):3495-3508.