PROTAC dCE-1

Chemical Structure : PROTAC dCE-1

加入收藏

货号: PC-21708Not For Human Use, Lab Use Only.

PROTAC dCE-1 is a potent, selective CBP/EP300 degrader targeting the histone acetyltransferase (HAT) domain, with DC50 value of 1.3 μM in LP1 cells.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

PROTAC dCE-1 is a potent, selective CBP/EP300 degrader targeting the histone acetyltransferase (HAT) domain, with DC50 value of 1.3 μM in LP1 cells.
dCE-1 induces foci formation in the FluoPPI assay with an EC50 of 1.2 μM.
dCE-1 has antiproliferative effects in a panel of cell lines through the NCI-60 screen.
dCE-1 is consisting of the HAT inhibitor CPI-1612 conjugated via a 24-atom linker to pomalidomide.

物理化学性质&存储条件

分子量	1071.20
分子式	C56H66N10O12
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(6-((R)-2-(((S)-2-(4-cyanophenyl)propyl)amino)-2-phenylacetamido)pyridin-3-yl)-1H-pyrazol-1-yl)-N-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-2,5,8,11,14,17-hexaoxanonadecan-19-yl)butanamide

参考文献

1. Iván Cheng-Sánchez, et al. ACS Medicinal Chemistry Letters, January 26, 2024

PROTAC dCE-1

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

PROTAC dCE-1

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.