PRC1590 | P.falciparum inhibitor | Probechem Biochemicals

Chemical Structure : PRC1590

加入收藏

PRC1590 (PRC-1590)

货号: PC-23893Not For Human Use, Lab Use Only.

PRC1590 is a tetrahydro-β-carboline compound that potently kills the malaria parasite with EC50 of 145 nM and 142 nM in growth inhibition assays in 3D7WT and Dd2 strains.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

PRC1590 is a tetrahydro-β-carboline compound that potently kills the malaria parasite with EC50 of 145 nM and 142 nM in growth inhibition assays in 3D7WT and Dd2 strains.
PRC1590 has a mechanism of action associated with P. falciparum's DV that differs from chloroquine, inhibits trophozoite stage.
The mechanism of resistance to PRC1590 is mediated by the G293V single-nucleotide polymorphism (SNP) of the P. falciparum multidrug resistance protein 1 (PfMDR1), a transporter located on the membrane of the digestive vacuole (DV).

物理化学性质&存储条件

分子量	505.80
分子式	C26H18BrClN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-(5-bromobenzofuran-2-yl)(1-(4-chlorophenyl)-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)methanone

参考文献

1. Emily K Bremers, et al. ACS Infect Dis. 2025 Jan 14. doi: 10.1021/acsinfecdis.4c01001.

2. Hanan Almolhim, et al. ACS Med Chem Lett. 2022 Feb 24;13(3):371-376.

PRC1590 (PRC-1590)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

PRC1590 (PRC-1590)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.