PPBI |CAS:959863-95-7 Probechem Biochemicals

Chemical Structure : PPBI

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PPBI (M1 agonist PPBI)

货号: PC-61789Not For Human Use, Lab Use Only.

PPBI is a potent, selective, full M1 muscarinic agonist with EC50 of 5, 8, and 21 nM for human, rat, and mouse M1 receptors, respectively.

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

PPBI is a potent, selective, full M1 muscarinic agonist with EC50 of 5, 8, and 21 nM for human, rat, and mouse M1 receptors, respectively.
PPBI displays a functional potency more than 10-fold than that of M4, >100-fold more potent over M2, M3 and M5.
PPBI reverses d-amphetamine locomotor activity, also reverses a natural deficit in a rat cognition model.
PPBI is analgesic in a variety of rat and mouse models.

物理化学性质&存储条件

分子量	376.432
分子式	C19H25FN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl (S)-3-(4-(6-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)pyrrolidine-1-carboxylate

参考文献

1. Wood MW, et al. Neuropharmacology. 2017 Sep 1;123:233-241.

PPBI (M1 agonist PPBI)

生物&药学活性

物理化学性质&存储条件

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PPBI (M1 agonist PPBI)

生物&药学活性

物理化学性质&存储条件

参考文献

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