PF670462 dihydrochloride

Chemical Structure : PF670462 dihydrochloride

CAS No.: 950912-80-8

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货号: PC-23901Not For Human Use, Lab Use Only.

PF-670462 dihydrochloride (PF670462) is a potent and selective inhibitor casein kinase CK1ε and CK1δ with IC50 of 7.7 nM and 14 nM, respectively.

规格	价格	库存
5 mg	￥580	In stock
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PF-670462 dihydrochloride (PF670462) is a potent and selective inhibitor casein kinase CK1ε and CK1δ with IC50 of 7.7 nM and 14 nM, respectively.
PF-670462 causes a significant phase delay in animal models of circadian rhythm.

物理化学性质&存储条件

分子量	410.32
分子式	C19H22Cl2FN5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl)pyrimidin-2-amine dihydrochloride

参考文献

1. Badura L, et al. J Pharmacol Exp Ther. 2007 Aug;322(2):730-8.

2. Bryant CD, et al. Psychopharmacology (Berl). 2009 May;203(4):703-11.

3. Walton KM, et al. J Pharmacol Exp Ther. 2009 Aug;330(2):430-9.