PF-5006739 |CAS:1293395-67-1 Probechem Biochemicals

Chemical Structure : PF-5006739

CAS No.: 1293395-67-1

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PF-5006739 (PF 5006739;PF5006739)

货号: PC-61114Not For Human Use, Lab Use Only.

PF-5006739 is a potent, selective casein kinase CK1δ/ε inhibitor with IC50 of 3.9/17.0 nM, respectively.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2280	In stock
50 mg	￥3780	In stock
100 mg		Get quote

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生物&药学活性

PF-5006739 is a potent, selective casein kinase CK1δ/ε inhibitor with IC50 of 3.9/17.0 nM, respectively.
PF-5006739 demonstrates excellent kinome selectivity in a 59-kinase panel with exception of JNK2 (IC50=6.1 uM) and ZC3 (IC50=1.5 uM).
PF-5006739 exhibits robust centrally mediated circadian rhythm phase-delaying effects in both nocturnal and diurnal animal models, attenuates opioid drug-seeking behavior in a rodent operant reinstatement model in animals trained to self-administer fentanyl.
PF-5006739 also improves glucose tolerance in both DIO and genetic (ob/ob) models of obesity.

物理化学性质&存储条件

分子量	419.464
分子式	C22H22FN7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-{4-(4-Fluorophenyl)-1-[1-(1,2-oxazol-3-ylmethyl)piperidin-4-yl]-1H-imidazol-5-yl}pyrimidin-2-amine

参考文献

1. Wager TT, et al. ACS Chem Neurosci. 2014 Dec 17;5(12):1253-65.

2. Cunningham PS, et al. Sci Rep. 2016 Jul 21;6:29983.

PF-5006739 (PF 5006739;PF5006739)

生物&药学活性

物理化学性质&存储条件

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PF-5006739 (PF 5006739;PF5006739)

生物&药学活性

物理化学性质&存储条件

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