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首页-小分子抑制剂&激动剂-GPCR-Vasopressin Receptor-PF-184563
PF-184563

Chemical Structure : PF-184563

CAS No.: 748806-39-5

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PF-184563 (PF 184563)

货号: PC-21617Not For Human Use, Lab Use Only.

PF-184563 is a potent and selective vasopressin V1a antagonist with IC50 of 6.7 nM (hV1a).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PF-184563 is a potent and selective vasopressin V1a antagonist with IC50 of 6.7 nM (hV1a).
PF-184563 shows little binding to V1b or OT receptors (>10 μM).
PF-184563 dsiplays no significant inhibition of Cytochrome P450 (IC50 values >30 μM for CYP 1A2, 2C9, 2C19, 2D6 and 3A4) or blockade of the hERG channel.
PF-184563 shows weak binding hV2 receptor (IC50=8490 nM).

物理化学性质&存储条件

分子量 394.91
分子式 C21H23ClN6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

8-chloro-5-methyl-1-(1-(pyridin-2-yl)piperidin-4-yl)-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine

参考文献

1. Johnson PS, et al. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5684-7.

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