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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Trk Receptor-PF-06273340
PF-06273340

Chemical Structure : PF-06273340

CAS No.: 1402438-74-7

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PF-06273340 (PF06273340, PF6273340)

货号: PC-61701Not For Human Use, Lab Use Only.

PF-06273340 is a potent and selective, orally bioavailable pan-Trk kinase inhibitor with IC50 of 6, 2, and 1 nM for Trk A, B and C, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PF-06273340 (PF6273340) is a potent and selective, orally bioavailable pan-Trk kinase inhibitor with IC50 of 6, 2, and 1 nM for Trk A, B and C, respectively.
    PF-06273340displays selectivity over a panel of ion channels, receptors and other enzymes; exhibits in vivo efficacy in a rodent model of inflammatory pain.

    物理化学性质&存储条件

    分子量 479.93
    分子式 C23H22ClN7O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(5-(2-amino-7-(1-hydroxy-2-methylpropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)-2-(5-chloropyridin-2-yl)acetamide

    参考文献

    1. Skerratt SE, et al. J Med Chem. 2016 Nov 23;59(22):10084-10099.

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