PF-03654746 (PF-3654746) | Histamine H3 antagonist | Probechem Biochemicals

Chemical Structure : PF-03654746

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PF-03654746 (PF-3654746, PF03654746)

货号: PC-63034Not For Human Use, Lab Use Only.

PF-03654746 (PF-3654746) is a potent, selective, orally bioactive antagonist of H3 receptor with Ki of 2.3 nM.

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生物&药学活性

PF-03654746 (PF-3654746) is a potent, selective, orally bioactive antagonist of H3 receptor with Ki of 2.3 nM.
PF-03654746 dislaplays >1000-fold selectivity versus H1, H2, H4 and other GPCRs (IC50>10 uM).
PF-03654746 possesses optimal pharmacological and pharmacokinetic profiles, shows potential in allergen-induced nasal symptoms.

物理化学性质&存储条件

分子量	322.4
分子式	C18H24F2N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Trans-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide

参考文献

1. Wager TT, et al. J Med Chem. 2011 Nov 10;54(21):7602-20.

2. Stokes JR, et al. J Allergy Clin Immunol. 2012 Feb;129(2):409-12, 412.e1-2.

3. Gallezot JD, et al. J Cereb Blood Flow Metab. 2017 Mar;37(3):1095-1107.

PF-03654746 (PF-3654746, PF03654746)

生物&药学活性

物理化学性质&存储条件

参考文献

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PF-03654746 (PF-3654746, PF03654746)

生物&药学活性

物理化学性质&存储条件

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