PDE-I2

Chemical Structure : PDE-I2

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货号: PC-72859Not For Human Use, Lab Use Only.

PDE-I2 is a potent and selective inhibitor of malaria proliferation with P. falciparum IC50 of 18 nM.

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生物&药学活性

PDE-I2 is a potent and selective inhibitor of malaria proliferation with P. falciparum IC50 of 18 nM.
PDE-I2 is a precursor of the anticancer duocarmycin family that preserves the class's sequence-specific DNA binding but lacks its signature DNA alkylating cyclopropyl warhead.
PDE-I2 retains comparable antimalarial potency to chloroquine.
PDE-I2 is >1,000-fold less toxic to human cell lines than duocarmycin, with mitigated impacts on eukaryotic chromosome stability.
PDE-I2 treatment induces severe defects in parasite nuclear segregation leading to impaired daughter cell formation during schizogony.

物理化学性质&存储条件

分子量	521.486
分子式	C25H23N5O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(6-carbamoyl-5-hydroxy-4-methoxy-3,6,7,8-tetrahydropyrrolo[3,2-e]indole-2-carbonyl)-5-hydroxy-4-methoxy-3,6,7,8-tetrahydropyrrolo[3,2-e]indole-2-carboxylic acid

参考文献

1. Arne Alder, et al. Cell Chem Biol. 2021 Oct 23;S2451-9456(21)00439-6.

PDE-I2

生物&药学活性

物理化学性质&存储条件

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PDE-I2

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