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首页-小分子抑制剂&激动剂-GPCR-Bombesin Receptor-PD176252
PD176252

Chemical Structure : PD176252

CAS No.: 204067-01-6

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PD176252 (PD 176252, PD-176252)

货号: PC-27296Not For Human Use, Lab Use Only.

PD176252 is a potent antagonist of neuromedin-B preferring (BB1, NMBR) and gastrin-releasing peptide-preferring (BB2) receptor (GRPR) with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively.

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10 mg ￥880 In stock
25 mg ￥1380 In stock
50 mg ￥2380 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PD176252 is a potent antagonist of neuromedin-B preferring (BB1, NMBR) and gastrin-releasing peptide-preferring (BB2) receptor (GRPR) with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively.
PD176252 inhibits (125I-Tyr0) neuromedin B binding with IC50 of 50 nM.
PD176252 (1 uM) significantly inhibited colony number using a proliferation assay in vitro.

物理化学性质&存储条件

分子量 584.68
分子式 C32H36N6O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-3-(1H-Indol-3-yl)-N-((1-(5-methoxypyridin-2-yl)cyclohexyl)methyl)-2-methyl-2-(3-(4-nitrophenyl)ureido)propanamide

参考文献

1. Ashwood V, et al. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2589-94.

2. Moody TW, et al. Eur J Pharmacol. 2000 Dec 8;409(2):133-42.

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