PD144418 |CAS:154130-99-1 Probechem Biochemicals

Chemical Structure : PD144418

CAS No.: 154130-99-1

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PD144418 (PD-144418;PD 144418)

货号: PC-60790Not For Human Use, Lab Use Only.

PD144418 is a potent, selective sigma 1 ligand with Ki of 0.08 nM, >3000-fold selectivity over sigma 2 (Ki=1377 nM).

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5 mg	￥2880	In stock
10 mg	￥4280	In stock
25 mg	￥7280	In stock
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100 mg		Get quote

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生物&药学活性

PD144418 is a potent, selective sigma 1 ligand with Ki of 0.08 nM, >3000-fold selectivity over sigma 2 (Ki=1377 nM).
PD144418 displays lacked affinity for dopaminergic, adrenergic, muscarinic and a variety of other receptors.
PD144418 reverses the NMDA-induced increase in cGMP in rat cerebellar slices without affecting the basal levels, potentiates the decrease in 5-hydroxytryptophan caused by haloperidol in the mesolimbic region in rats.
PD144418 antagonizes mescaline-induced scratching withour effect on spontaneous motor activity.

物理化学性质&存储条件

分子量	282.387
分子式	C18H22N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-propyl-5-(3-p-tolyl-isoxazol-5-yl)-1,2,3,6-tetrahydropyridine

参考文献

1. Akunne HC, et al. Neuropharmacology. 1997 Jan;36(1):51-62.

2. Lever JR, et al. J Pharmacol Exp Ther. 2014 Oct;351(1):153-63.

3. Schmidt HR, et al. Nature. 2016 Apr 28;532(7600):527-30.

PD144418 (PD-144418;PD 144418)

生物&药学活性

物理化学性质&存储条件

参考文献

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PD144418 (PD-144418;PD 144418)

生物&药学活性

物理化学性质&存储条件

参考文献

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