PC1244 |CAS:2046185-88-8 Probechem Biochemicals

Chemical Structure : PC1244

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PC1244 (PC 1244)

货号: PC-62607Not For Human Use, Lab Use Only.

PC1244 is a long acting fungicidal azole that targets A. fumigatus CYP51A and CYP51B, inhibits ergosterol synthesis in A. fumigatus with IC50 of 8 nM.

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生物&药学活性

PC1244 is a long acting fungicidal azole that targets A. fumigatus CYP51A and CYP51B, inhibits ergosterol synthesis in A. fumigatus with IC50 of 8 nM.
PC1244 demonstrates potent antifungal activities against clinical A. fumigatus isolates with a MIC range of 0.016-0.25 ug/mL.
PC1244 is also effective against a broad spectrum of pathogenic fungi (MIC= <0.0078-2 μg/ml), especially on Aspergillus terreus, Trichophyton rubrum, Candida albicans.
PC1244 shows fungicidal activity (MFC=2 μg/ml), 8-fold more potent than voriconazole.
PC1244 shows superior in vivo effects in immunocompromised mice.

物理化学性质&存储条件

分子量	686.805
分子式	C38H44F2N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)-3-methylphenyl)piperazin-1-yl)-N-((1S,2S)-2-hydroxycyclohexyl)benzamide

参考文献

1. Colley T, et al. Antimicrob Agents Chemother. 2018 Feb 12. pii: AAC.01941-17.

PC1244 (PC 1244)

生物&药学活性

物理化学性质&存储条件

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PC1244 (PC 1244)

生物&药学活性

物理化学性质&存储条件

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