PB28 |CAS:172906-90-0 Probechem Biochemicals

Chemical Structure : PB28

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PB28 (PB-28;PB 28)

货号: PC-60345Not For Human Use, Lab Use Only.

PB 28 is a potent, mixed sigma2 agonist and sigma1 antagonist with Ki of 0.28 and 13.0 nM, respectively.

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生物&药学活性

PB28 is a potent, mixed sigma2 agonist and sigma1 antagonist with Ki of 0.28 and 13.0 nM, respectively.
PB28 inhibits cancer cell growth, modulates P-glycoprotein, and synergizes with doxorubicin in MCF7 and MCF ADR cells with IC50 in nanomolar range.
PB28 increases G0-G1-phase fraction and caspase-independent apoptosis, also reduces P-gp expression.

物理化学性质&存储条件

分子量	370.57
分子式	C24H38N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine

参考文献

1. Azzariti A, et al. Mol Cancer Ther. 2006 Jul;5(7):1807-16.

2. Cassano G, et al. Cell Calcium. 2006 Jul;40(1):23-8.

3. Berardi F, et al. J Med Chem. 1996 Jan 5;39(1):176-82.

PB28 (PB-28;PB 28)

生物&药学活性

物理化学性质&存储条件

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PB28 (PB-28;PB 28)

生物&药学活性

物理化学性质&存储条件

参考文献

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