Ozanimod | S1P1/S1P5 agonist | Probechem Biochemicals

Chemical Structure : Ozanimod

CAS No.: 1306760-87-1

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Ozanimod (RPC-1063, RPC1063)

货号: PC-42950Not For Human Use, Lab Use Only.

Ozanimod (RPC-1063) is a potent, selective agonist of S1P1 and S1P5 receptor with EC50 of 0.41 nM and 11 nM respectively.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

Ozanimod (RPC-1063) is a potent, selective agonist of S1P1 and S1P5 receptor with EC50 of 0.41 nM and 11 nM respectively.
Ozanimod (RPC-1063) is less potent for S1P2, S1P3 and S1P4 (EC50> 10 uM).
Ozanimod (RPC-1063) induces S1P1 receptor internalization and induced a reversible reduction in circulating B and CCR7(+) T lymphocytes in vivo.
Ozanimod (RPC-1063) shows high oral bioavailability and volume of distribution, and a circulatory half-life.

物理化学性质&存储条件

分子量	404.4617
分子式	C23H24N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 29 mg/mL
Chemical Name/SMILES	Benzonitrile, 5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)-

参考文献

1. Scott FL, et al. Br J Pharmacol. 2016 Jun;173(11):1778-92.

2. Sandborn WJ, et al. N Engl J Med. 2016 May 5;374(18):1754-62.

3. Sandborn WJ, et al. N Engl J Med. 2016 Aug 25;375(8):e17.

Ozanimod (RPC-1063, RPC1063)

生物&药学活性

物理化学性质&存储条件

参考文献

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Ozanimod (RPC-1063, RPC1063)

生物&药学活性

物理化学性质&存储条件

参考文献

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