Olcegepant (BIBN-4096, BIBN4096BS) | CGRP antagonist | Probechem Biochemicals

Chemical Structure : Olcegepant

CAS No.: 204697-65-4

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Olcegepant (BIBN-4096, BIBN-4096BS, BIBN4096BS, BIBN 4096BS)

货号: PC-42294Not For Human Use, Lab Use Only.

Olcegepant (BIBN-4096, BIBN4096BS) is the first small molecule selective calcitonin gene-related peptide (CGRP) receptor antagonist with Ki of 14.4 nM for hCGRP.

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5 mg	￥1580	In stock
10 mg	￥2280	In stock
25 mg	￥3880	In stock
100 mg		Get quote

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生物&药学活性

Olcegepant (BIBN-4096, BIBN4096BS) is the first small molecule selective calcitonin gene-related peptide (CGRP) receptor antagonist with Ki of 14.4 nM for hCGRP.
Olcegepant (BIBN4096BS) inhibits the effects of CGRP, released by stimulation of the trigeminal ganglion, on facial blood flow in marmoset monkeys (1-30mg/kg, i.v.).

物理化学性质&存储条件

分子量	869.6451
分子式	C38H47Br2N9O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 50 mg/mL
Chemical Name/SMILES	Piperazine, 1-[3,5-dibromo-N-[[4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl)-1-piperidinyl]carbonyl]-D-tyrosyl-L-lysyl]-4-(4-pyridinyl)-

参考文献

1. Doods H, et al. Br J Pharmacol. 2000 Feb;129(3):420-3.

2. Powell KJ, et al. Br J Pharmacol. 2000 Nov;131(5):875-84.

3. Edvinsson L, et al. Eur J Pharmacol. 2002 Jan 2;434(1-2):49-53.

Olcegepant (BIBN-4096, BIBN-4096BS, BIBN4096BS, BIBN 4096BS)

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物理化学性质&存储条件

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Olcegepant (BIBN-4096, BIBN-4096BS, BIBN4096BS, BIBN 4096BS)

生物&药学活性

物理化学性质&存储条件

参考文献

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