OSM-S-106 | PfAsnRS inhibitor | Probechem Biochemicals

Chemical Structure : OSM-S-106

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OSM-S-106 (TCMDC-135294)

货号: PC-21022Not For Human Use, Lab Use Only.

OSM-S-106 is a reaction hijacking inhibitor of Plasmodium falciparum asparagine tRNA synthetase (PfAsnRS), inhibits the 3D7 line of P. falciparum with IC50 of 58 nM.

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生物&药学活性

OSM-S-106 is a reaction hijacking inhibitor of Plasmodium falciparum asparagine tRNA synthetase (PfAsnRS), inhibits the 3D7 line of P. falciparum with IC50 of 58 nM.
OSM-S-106 also prevents the development of P. berghei in liver cells (HepG2-A16-CD81-EGF; IC50 = 0.25/0.42 µM).
OSM-S-106 exhibited low cytotoxicity against the HepG2 cell line.
OSM-S-106 exhibits a low propensity for developing resistance.
OSM-S-106 inhibits protein translation and induces the amino acid starvation response.
OSM-S-106 inhibits ATP consumption by PfAsnRS but not HsAsnRS.

物理化学性质&存储条件

分子量	306.36
分子式	C12H10N4O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-aminothieno[3,2-d]pyrimidin-6-yl)benzenesulfonamide

参考文献

1. Leann Tilley, et al. Res Sq. 2023 Jul 27;rs.3.rs-3198291.

OSM-S-106 (TCMDC-135294)

生物&药学活性

物理化学性质&存储条件

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OSM-S-106 (TCMDC-135294)

生物&药学活性

物理化学性质&存储条件

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