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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Trk Receptor-ONO-7579
ONO-7579

Chemical Structure : ONO-7579

CAS No.: 1622212-25-2

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ONO-7579 (ONO7579)

货号: PC-72113Not For Human Use, Lab Use Only.

ONO-7579 (ONO7579) is a novel potent, selective, orally available pan-TRK inhibitor.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ONO-7579 (ONO7579) is a novel potent, selective, orally available pan-TRK inhibitor.
    BDNF significantly increased TRKB phosphorylation in GBC cells and the effects were abrogated by ONO-7579, suppress proliferation in a dose-dependent manner in TYGBK-1 cells.
    ONO-7579 inhibited BDNF/TRKB-induced migration and invasiveness, particularly in GBC cells harboring wild-type KRAS.
    ONO-7579 reduced invasiveness of gallbladder cancer (GBC) cells through inhibiting epithelial–mesenchymal transition (EMT) via the extracellular signal-regulated kinase (ERK) or protein kinase B (AKT) pathway.

    物理化学性质&存储条件

    分子量 578.951
    分子式 C24H18ClF3N6O4S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-{2-[4-(2-amino-5-chloropyridin-3-yl)phenoxy]pyrimidin-5-yl}-N'-[2- (methanesulfonyl)-5-(trifluoromethyl)phenyl]urea

    参考文献

    1. Kawamoto M, et al. Anticancer Res. 2018 Apr;38(4):1979-1986.

    2. Iida H, et al. J Pharmacol Exp Ther. 2020 Jun;373(3):361-369.

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