OJT008 | Mtb MetAP1 inhibitor | Probechem Biochemicals

Chemical Structure : OJT008

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OJT008 (OJT 008)

货号: PC-21577Not For Human Use, Lab Use Only.

OJT008 is a small molecule Mtb. MetAP inhibitor against M. tuberculosis, has MIC50 of 0.063 µg/mL against both active and MDR Mtb.

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生物&药学活性

OJT008 is a small molecule Mtb. MetAP inhibitor against M. tuberculosis, has MIC50 of 0.063 µg/mL against both active and MDR Mtb.
OJT008 inhibits MtMetAP1c activated with CoCl2 and NiCl2 were 11 µM and 40 µM, respectively, strongly binds to both metal-activated MtMetAP1c.
OJT008 also inhibits the enzyme methionine aminopeptidase 1 of L. major (MetAP1Lm).
OJT008 showed potent leishmanicidal activity and remarkable selectivity indexes in vitro (EC50=0.24 uM).
OJT008 exhibits significant antileishmanial activity in vitro and in vivo.

物理化学性质&存储条件

分子量	324.81
分子式	C18H17ClN4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-benzyl-5-chloro-N,6-dimethyl-2-(pyridin-2-yl)pyrimidin-4-amine

参考文献

1. Rodriguez F, et al. Antimicrob Agents Chemother. 2020 May 21;64(6):e01422-19.

2. Onyenaka C, et al. Int J Mol Sci. 2023 Dec 5;24(24):17142.

OJT008 (OJT 008)

生物&药学活性

物理化学性质&存储条件

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OJT008 (OJT 008)

生物&药学活性

物理化学性质&存储条件

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