Nexinhib20 | Rab27a-JFC1 inhibitor | Probechem Biochemicals

Chemical Structure : Nexinhib20

CAS No.: 331949-35-0

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Nexinhib20 (Nexinhib 20, Nexinhib-20)

货号: PC-60847Not For Human Use, Lab Use Only.

Nexinhib20 is a specific small molecule neutrophil exocytosis inhibitor (IC50=0.33 uM) that specifically inhibits Rab27a-JFC1 binding (IC50=2.6 uM) but does not interfere with the interaction of other Rab GTPases and effectors.

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10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
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生物&药学活性

Nexinhib20 is a specific small molecule neutrophil exocytosis inhibitor (IC50=0.33 uM) that specifically inhibits Rab27a-JFC1 binding (IC50=2.6 uM) but does not interfere with the interaction of other Rab GTPases and effectors.
Nexinhib20 does not induce apoptosis or cell death, regulates exocytosis-dependent neutrophil functions and inhibits MPO secretion from human neutrophils.
Nexinhib20 also reversiblely and potently inhibits extracellular production of superoxide anion and the up-regulation of activation signature molecules, including CD11b and CD66b.
Nexinhib20 significantly decreased tissue infiltration by inflammatory neutrophils in vivo.

物理化学性质&存储条件

分子量	300.318
分子式	C15H16N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,4-dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-one

参考文献

1. Johnson JL, et al. J Biol Chem. 2016 Dec 9;291(50):25965-25982.

Nexinhib20 (Nexinhib 20, Nexinhib-20)

生物&药学活性

物理化学性质&存储条件

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Nexinhib20 (Nexinhib 20, Nexinhib-20)

生物&药学活性

物理化学性质&存储条件

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