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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-Nemacol-1
Nemacol-1

Chemical Structure : Nemacol-1

CAS No.: 415932-86-4

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Nemacol-1 (Nemacol 1)

货号: PC-20446Not For Human Use, Lab Use Only.

Nemacol-1 is a small molecule inhibitor of C. elegans vesicular acetylcholine transporter (VAChT), demonstrates nematode-selective activity (C. elegans, EC50=7.1 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Nemacol-1 is a small molecule inhibitor of C. elegans vesicular acetylcholine transporter (VAChT), demonstrates nematode-selective activity (C. elegans, EC50=7.1 uM).
    Nemacol-1 can suppress the paralysis induced by two structurally distinct AChE inhibitors, namely trichlorfon (an organophosphate) and aldicarb (a carbamate) in a dose-dependent manner.
    Nemacol-1 is 5.4-fold more potent than Vesamicol in live C. elegans worms, but has 37-fold less affinity than Vesamicol for the mammalian VAChT target (Ki=875 nM, rat VAChT).
    Nemacol-1 enhances the ability of the anthelmintic Ivermectin to paralyze C. elegans and the ruminant nematode parasite Haemonchus contortus.

    物理化学性质&存储条件

    分子量 303.41
    分子式 C17H25N3O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(cyclohexylmethyl)-4-(4-nitrophenyl)piperazine

    参考文献

    1. Harrington S, et al. Nat Commun. 2023 Mar 31;14(1):1816.

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