NVS-STG2 | STING agonist | Probechem Biochemicals

Chemical Structure : NVS-STG2

CAS No.: 3030588-01-0

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NVS-STG2 (NVS STG2)

货号: PC-21582Not For Human Use, Lab Use Only.

NVS-STG2 is a small molecule STING agonist with AC50 of 5.2 uM in ISRE-Luc reporter assays, induces STING-dependent IRF3 phosphorylation in THP1 cells.

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1 mg	￥1280	In stock
5 mg	￥2580	In stock
10 mg	￥4280	In stock
25 mg	￥7280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

NVS-STG2 is a small molecule STING agonist with AC50 of 5.2 uM in ISRE-Luc reporter assays, induces STING-dependent IRF3 phosphorylation in THP1 cells.
NVS-STG2 targets STING transmembrane domain (TMD).
NVS-STG2 is a molecular glue promotes STING oligomerization, enhances the interface of the two STING dimers, thereby promoting the high-order oligomerization of STING.
NVS-STG2 activates human but not mouse STING.
NVS-STG2 induces antitumor activity and immune response in hSTING knock-in mice, exhibits a dose-dependent and significant induction of T cell priming response.

物理化学性质&存储条件

分子量	427.54
分子式	C25H33NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((4-(2-(tert-butyl)-5,5-dimethyl-1,3-dioxan-2-yl)benzyl)amino)-3-methoxybenzoic acid

参考文献

1. Jie Li, et al. Nat Chem Biol. 2023 Oct 12. doi: 10.1038/s41589-023-01434-y.

NVS-STG2 (NVS STG2)

生物&药学活性

物理化学性质&存储条件

参考文献

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NVS-STG2 (NVS STG2)

生物&药学活性

物理化学性质&存储条件

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