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首页-小分子抑制剂&激动剂-Immunology/Inflammation-NOD-like Receptor (NLR)-NT-0796
NT-0796

Chemical Structure : NT-0796

CAS No.: 2272917-13-0

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NT-0796 (NT0796, NT 0796)

货号: PC-21283Not For Human Use, Lab Use Only.

NT-0796 is a potent, selective and brain-penetrant NLRP3 inflammasome inhibitor, inhibits IL-1β release from human PBMC cells with IC50 of 0.32 nM.

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5 mg ￥3980 In stock
10 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NT-0796 is a potent, selective and brain-penetrant NLRP3 inflammasome inhibitor, inhibits IL-1β release from human PBMC cells with IC50 of 0.32 nM.
NT-0796 is an isopropyl ester that undergoes intracellular conversion to NDT-19795.
NT-0796 is a potent and selective NLRP3 inflammasome inhibitor with demonstrated in vivo brain penetration.
NT-0796 shows no inhibition of IL-6 or TNFα from human PBMCs.

物理化学性质&存储条件

分子量 409.49
分子式 C23H27N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

isopropyl (R)-2-(((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)oxy)-3-(pyrimidin-2-yl)propanoate

参考文献

1. David Harrison, et al. J Med Chem. 2023 Oct 24. doi: 10.1021/acs.jmedchem.3c01398.

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