NSC49652 | p75NTR agonist | Probechem Biochemicals

Chemical Structure : NSC49652

CAS No.: 908563-68-8

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NSC49652 (NSC 49652, NSC-49652)

货号: PC-35729Not For Human Use, Lab Use Only.

NSC49652 (NSC 49652) is a functional p75NTR agonist targeting the transmembrane domain (TMD) of death receptor p75NTR with IC50 of 10 uM in AraTM assays, alters the relative conformation of p75NTR TMDs and induces dynamic changes in the full-length receptor in mammalian cells.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

NSC49652 (NSC 49652) is a functional p75NTR agonist targeting the transmembrane domain (TMD) of death receptor p75NTR with IC50 of 10 uM in AraTM assays, alters the relative conformation of p75NTR TMDs and induces dynamic changes in the full-length receptor in mammalian cells.
NSC49652 induces apoptosis through p75NTR and the JNK pathway in neurons and affects the viability of melanoma cells.
NSC49652 reduces tumor growth and improves survival in human melanoma xenograft model, orally available.

物理化学性质&存储条件

分子量	225.247
分子式	C14H11NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-1-(2-hydroxyphenyl)-3-(pyridin-3-yl)prop-2-en-1-one

参考文献

1. Goh ETH, et al. Cell Chem Biol. 2018 Oct 1. pii: S2451-9456(18)30302-7.

NSC49652 (NSC 49652, NSC-49652)

生物&药学活性

物理化学性质&存储条件

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NSC49652 (NSC 49652, NSC-49652)

生物&药学活性

物理化学性质&存储条件

参考文献

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