NPS-2143 hydrochloride |CAS:324523-20-8 Probechem Biochemicals

Chemical Structure : NPS-2143 hydrochloride

CAS No.: 324523-20-8

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NPS-2143 hydrochloride (NPS2143 hydrochloride;NPS 2143 hydrochloride;SB262470A)

货号: PC-42415Not For Human Use, Lab Use Only.

NPS-2143 (SB262470A) hydrochloride is a potent, selective and orally active CaSR antagonist with IC50 of 43 nM.

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10 mg	￥1080	In stock
25 mg	￥1880	In stock
50 mg	￥3180	In stock
100 mg		Get quote

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生物&药学活性

NPS-2143 (SB262470A) hydrochloride is a potent, selective and orally active CaSR antagonist with IC50 of 43 nM.
NPS-2143 does not inhibit cytoplasmic Ca2+ responses to glutamate in HEK 293 cells engineered to express mGluRs and GABAB receptors.
NPS-2143 stimulates parathyroid hormone (PTH ) secretion from bovine parathyroid cells in vitro (EC50=39 nM) and increases plasma PTH levels in vivo.
NPS-2143 also inhibits lipopolysaccharide-induced pulmonary inflammation.

物理化学性质&存储条件

分子量	445.3814
分子式	C24H26Cl2N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-chloro-6-(2-hydroxy-3-((2-methyl-1-(naphthalen-2-yl)propan-2-yl)amino)propoxy)benzonitrile hydrochloride

参考文献

1. Gowen M, et al. J Clin Invest. 2000 Jun;105(11):1595-604.

2. Nemeth EF, et al. J Pharmacol Exp Ther. 2001 Oct;299(1):323-31.

3. Lee JW, et al. Mol Immunol. 2017 Oct;90:150-157.

NPS-2143 hydrochloride (NPS2143 hydrochloride;NPS 2143 hydrochloride;SB262470A)

生物&药学活性

物理化学性质&存储条件

参考文献

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NPS-2143 hydrochloride (NPS2143 hydrochloride;NPS 2143 hydrochloride;SB262470A)

生物&药学活性

物理化学性质&存储条件

参考文献

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