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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-NPD8790
NPD8790

Chemical Structure : NPD8790

CAS No.: 615281-26-0

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NPD8790 (NPD-8790)

货号: PC-22334Not For Human Use, Lab Use Only.

NPD8790 is a species-selective inhibitor of mitochondrial respiratory complex I with IC50 of 1.6, 2.1 and 1.1 uM for C. briggsae, P. pacificus and P. hermaphrodita complex I, respectively, does not inhibit human mitochondria with IC50 of >75 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NPD8790 is a species-selective inhibitor of mitochondrial respiratory complex I with IC50 of 1.6, 2.1 and 1.1 uM for C. briggsae, P. pacificus and P. hermaphrodita complex I, respectively, does not inhibit human mitochondria with IC50 of >75 uM.
NPD8790 shows lethal activity in the C. elegans RQ-dependent metabolism assay in vivo.
NPD8790 affects H. polygyrus, a mouse soil-transmitted helminth.

物理化学性质&存储条件

分子量 292.43
分子式 C20H24N2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(1-(4-isobutylphenyl)ethyl)-1-methyl-1H-benzo[d]imidazole

参考文献

1. Taylor Davie, et al. Nat Commun. 2024 May 8;15(1):3367.

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