NPD6433 | Fas1 inhibitor | Probechem Biochemicals

Chemical Structure : NPD6433

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NPD6433 (NPD 6433, NPD-6433)

货号: PC-20942Not For Human Use, Lab Use Only.

NPD6433 is a novel broad-spectrum antifungal agent with MIC <10 ug/mL against C. albicans, Candida glabrata, Candida auris, and C. neoformans, inhibits Fas1 enoyl reductase activity.

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生物&药学活性

NPD6433 is a novel broad-spectrum antifungal agent with MIC <10 ug/mL against C. albicans, Candida glabrata, Candida auris, and C. neoformans, inhibits Fas1 enoyl reductase activity.
NPD6433 also shows bioactivity against A. fumigatus.
NPD6433 inhibits fatty acid synthesis through disruption of FMN-dependent NADPH oxidation by the ER domain of Fas1.
NPD6433 inhibits fatty acid synthesis by covalently adducting Fas1, inhibits virulence traits in diverse fungal pathogen.
NPD6433 is active against C. albicans in early stage infection models.

物理化学性质&存储条件

分子量	407.47
分子式	C22H25N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(C(N1)=C(/N=N/N2C[C@@H](C)C(N3C[C@@H](C)C2)=CC=CC3=O)C4=C1C=CC=C4)OC

参考文献

1. Kali R Iyer, et al. Cell Chem Biol. 2023 Jun 24;S2451-9456(23)00160-5.

NPD6433 (NPD 6433, NPD-6433)

生物&药学活性

物理化学性质&存储条件

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NPD6433 (NPD 6433, NPD-6433)

生物&药学活性

物理化学性质&存储条件

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