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首页-抗体药物偶连体和PROTACs-PROTAC-NP1192
NP1192

Chemical Structure : NP1192

CAS No.: 2966791-41-1

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NP1192 (NP-1192)

货号: PC-25951Not For Human Use, Lab Use Only.

NP1192 is a highly effective PROTAC degrader targeting NAT10, promotes NAT10 KD and inhibits ac4C modification, facilitates NAT10 degradation through the ubiquitin-proteasome system (UPS).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NP1192 is a highly effective PROTAC degrader targeting NAT10, promotes NAT10 KD and inhibits ac4C modification, facilitates NAT10 degradation through the ubiquitin-proteasome system (UPS).

物理化学性质&存储条件

分子量 734.88
分子式 C39H42N8O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzonitrile, 4-[2-[2-cyclopentylidene-1-[7-[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-1-piperazinyl]-7-oxoheptyl]hydrazinyl]-4-thiazolyl]-

参考文献

1. Ao K, et al. ACS Cent Sci. 2025 Sep 16;11(11):2087-2107.

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