NOD1 antagonist 66

Chemical Structure : NOD1 antagonist 66

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货号: PC-23602Not For Human Use, Lab Use Only.

NOD1 antagonist 66 is a potent and selective antagonist of both human and mouse NOD1, inhibits h/mNOD1-induced NF-κB activation in HEK293 cells with IC50 of 0.8 nM and 32 nM respectively.

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50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

NOD1 antagonist 66 is a potent and selective antagonist of both human and mouse NOD1, inhibits h/mNOD1-induced NF-κB activation in HEK293 cells with IC50 of 0.8 nM and 32 nM respectively.
Compound 66 exhibits high selectivity over NOD2, RIP2, TLR2, TLR4 and TLR9.
Compound 66 antagonizes C12-iE-DAP-induced NF-κB activation.
Compound 66 suppresses inflammation via NOD1 activation, inhibits NOD1-Induced NF-κB and MAPK pathways.
Compound 66 blocks C12-iE-DAP activation of NOD1 signaling and H. pylori-mediated inflammatory cytokine.
Compound 66 ((12.5, 25, and 50 mg/kg), oral) inhibited C12-iE-DAP-induced and H. pylori infection inflammatory responses in mice.

物理化学性质&存储条件

分子量	560.37
分子式	C21H13Cl2F2N3O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-Chloro-5-(2-chloro-6-(methylsulfonyl)-4-oxoquinazolin-3(4H)-yl)phenyl)-2,6-difluorobenzenesulfonamide

参考文献

1. Liu X, et al. J Med Chem. 2024 Dec 5. doi: 10.1021/acs.jmedchem.4c02139.