NLX-204 |CAS:2170405-10-2 Probechem Biochemicals

Chemical Structure : NLX-204

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NLX-204 (NLX204;NLX 204)

货号: PC-36071Not For Human Use, Lab Use Only.

NLX-204 (NLX204) is a potent, selective, ERK1/2 phosphorylation-preferring serotonin 5-HT1A receptor agonist with pEC50 of 9.37.

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生物&药学活性

NLX-204 (NLX204) is a potent, selective, ERK1/2 phosphorylation-preferring serotonin 5-HT1A receptor agonist with pEC50 of 9.37.
NLX-204 shows promising pharmacokinetic profile, also robustly stimulates ERK1/2 phosphorylation in rat cortex and showed highly potent (MED=0.16 mg/kg) and efficacious antidepressant-like activity, totally eliminating immobility in the rat Porsolt test.

物理化学性质&存储条件

分子量	409.862
分子式	C20H22ClF2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-chloro-4-fluorophenyl)(4-fluoro-4-(((2-(pyridin-2-yloxy)ethyl)amino)methyl)piperidin-1-yl)methanone

参考文献

1. Sniecikowska J, et al. J Med Chem. 2019 Feb 5. doi: 10.1021/acs.jmedchem.9b00062.

NLX-204 (NLX204;NLX 204)

生物&药学活性

物理化学性质&存储条件

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NLX-204 (NLX204;NLX 204)

生物&药学活性

物理化学性质&存储条件

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