NK250

Chemical Structure : NK250

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货号: PC-26810Not For Human Use, Lab Use Only.

NK250 is a potent, selective, Cullin-Ring-E3 ligase (CRL)-dependent USP7 PROTAC degrader with DC50 of 4 nM in MV4-11 cells (24 h).

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

NK250 is a potent, selective, Cullin-Ring-E3 ligase (CRL)-dependent USP7 PROTAC degrader with DC50 of 4 nM in MV4-11 cells (24 h).
NK250 (250 nM) induces complete degradation of USP7 with PROTAC NK250 in Panc89 cells.

物理化学性质&存储条件

分子量	1136.43
分子式	C62H77N11O8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-4-hydroxy-1-((S)-2-((1r,4S)-4-(4-(4-(5-((4-hydroxy-1-((R)-3-phenylbutanoyl)piperidin-4-yl)methyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)piperazine-1-carbonyl)cyclohexane-1-carboxamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

参考文献

1. Nikolas Klink, et al. bioRxiv doi: https://doi.org/10.1101/2025.07.01.662351

NK250

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物理化学性质&存储条件

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NK250

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