NIC7 | NLRP3 inhibitor | Probechem Biochemicals

Chemical Structure : NIC7

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NIC7 (NLRP3-inhibitory compound 7)

货号: PC-49463Not For Human Use, Lab Use Only.

NLRP3-inhibitory compound 7 (NIC7) is a small-molecule inhibitor of Nod-like receptor family pyrin domain-containing 3 (NLRP3), inhibits NLRP3-mediated activation of caspase 1 along with the secretion of IL-1β, IL-18, and lactate dehydrogenase.

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生物&药学活性

NLRP3-inhibitory compound 7 (NIC7) is a small-molecule inhibitor of Nod-like receptor family pyrin domain-containing 3 (NLRP3), inhibits NLRP3-mediated activation of caspase 1 along with the secretion of IL-1β, IL-18, and lactate dehydrogenase.
NIC7 significantly reversed the associated disease symptoms in the mice Alzheimer's disease (AD) model.
NIC7 did not reverse the disease symptoms in the imiquimod (IMQ)-induced disease model of psoriasis.

物理化学性质&存储条件

分子量	480.557
分子式	C23H20N4O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-(3-(3-acetylphenyl)ureido)benzo[d]thiazol-2-yl)-4-methylbenzenesulfonamide

参考文献

1. Muhammad Haseeb, et al. ACS Chem Neurosci. 2022 Mar 16;13(6):818-833.

NIC7 (NLRP3-inhibitory compound 7)

生物&药学活性

物理化学性质&存储条件

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NIC7 (NLRP3-inhibitory compound 7)

生物&药学活性

物理化学性质&存储条件

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