NIBR-0213 | S1P1 antagonist | Probechem Biochemicals

Chemical Structure : NIBR-0213

CAS No.: 1233332-14-3

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NIBR-0213 (NIBR 0213, NIBR0213)

货号: PC-61179Not For Human Use, Lab Use Only.

NIBR-0213 is a potent, selective, orally active S1P1 antagonist with IC50 of 2.5 nM Ca2+ mobilization assays, without activity on S1P2, S1P3 and S1P4 (IC50>10 uM).

规格	价格	库存
1 mg	￥1280	In stock
5 mg	￥2280	In stock
10 mg	￥3780	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

NIBR-0213 is a potent, selective, orally active S1P1 antagonist with IC50 of 2.5 nM Ca2+ mobilization assays, without activity on S1P2, S1P3 and S1P4 (IC50>10 uM).
NIBR-0213 displays potent and comparable potency on human and rat S1P1 with IC50 of 2.0 and 2.3 nM in GTPγ35S assays, 3,000-fold selectivity against human S1P5.
NIBR-0213 inhibits FTY720-phosphate-induced S1P1 internalization at 1 uM, induces long-lasting reduction of peripheral blood lymphocyte counts, shows comparable therapeutic efficacy to Fingolimod in experimental autoimmune encephalomyelitis (EAE).

物理化学性质&存储条件

分子量	464.98
分子式	C27H29ClN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[[3'-[[(1R)-1-(4-chloro-3-methylphenyl)ethyl]amino]-3,5-dimethyl[1,1'-biphenyl]-4-yl]carbonyl]-L-alanine

参考文献

1. Quancard J, et al. Chem Biol. 2012 Sep 21;19(9):1142-51.

2. Bigaud M, et al. PLoS One. 2016 Dec 22;11(12):e0168252.

NIBR-0213 (NIBR 0213, NIBR0213)

生物&药学活性

物理化学性质&存储条件

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NIBR-0213 (NIBR 0213, NIBR0213)

生物&药学活性

物理化学性质&存储条件

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