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N205

Chemical Structure : N205

CAS No.: 2237966-37-7

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N205 (N-205, N 205)

货号: PC-35114Not For Human Use, Lab Use Only.

N205 is a novel anti-malaria compound with in vitro IC50 of 1.3 nM against Plasmodium falciparum (3D7).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    N205 is a novel anti-malaria compound with in vitro IC50 of 1.3 nM against Plasmodium falciparum (3D7).
    N205 demonstrates excellent rodent pharmacokinetic and in vivo antimalarial efficacy studies in the mouse Plasmodium berghei and Plasmodium falciparum Pf3D70087/N9 severe combined immunodeficiency (SCID) mouse models.

    物理化学性质&存储条件

    分子量 455.595
    分子式 C27H37NO5
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(4-((1r,3r,5r,7r)-dispiro[adamantane-2,3'-[1,2,4,5]tetraoxane-6',1''-cyclohexan]-4''-yl)benzyl)morpholine

    参考文献

    1. O' Neill PM, et al. Bioorg Med Chem. 2018 May 17. pii: S0968-0896(18)30203-7.

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