MyD88 inhibitor C17

Chemical Structure : MyD88 inhibitor C17

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货号: PC-21177Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

MyD88 inhibitor C17 is a highly potent inhibitor of myeloid differentiation primary response protein 88 (MyD88), dose-dependently inhibits LPS-induced IL-6 and TNF-α in J774A.1 macrophages with IC50 of 2.17 and 8.17 uM, respectively.
MyD88 inhibitor C17 directly interacts with MyD88 in a dose-dependent manner with Kd of 53 uM in SPR assays.
MyD88 inhibitor C17 also shows inhibition on the release of cytokines in LPS-stimulated human THP-1 cells, suppresses TLR-MyD88 signaling in response to LPS stimulation.
MyD88 inhibitor C17 inhibits the interaction of TLR4 and MyD88 and suppressed the NF-κB pathway.
MyD88 inhibitor C17 treatment (20 mg/kg, orally) led to the accumulation in the lungs of rats and attenuated LPS-induced ALI mice model, with negligible toxicity in vivo.

物理化学性质&存储条件

分子量	528.54
分子式	C23H24N6O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-Methoxypyridin-3-yl)-3-nitro-4-(4-(3-nitrobenzyl)piperazin-1-yl)benzenesulfonamide

参考文献

1. Pan Chen, et al. J Med Chem. 2023 May 25;66(10):6938-6958.