MyD88 inhibitor A5S

Chemical Structure : MyD88 inhibitor A5S

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货号: PC-23608Not For Human Use, Lab Use Only.

MyD88 inhibitor A5S is a specific small molecule MyD88 inhibitor with SPR Kd of 15 uM, exerts anti-inflammatory effect through the NF-κB/MAPK pathway.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

MyD88 inhibitor A5S is a specific small molecule MyD88 inhibitor with SPR Kd of 15 uM, exerts anti-inflammatory effect through the NF-κB/MAPK pathway.
A5S reduces release of the LPS-induced IL-6 and TNF-α in J774A.1 cells with IC50 of 0.24 uM and 3.28 μM, respectively.
A5S restores IκB-α levels and suppressed the phosphorylation of p65.
A5S interferes with MyD88 homologous dimerization and inhibits MAPK pathway activation.
A5S protects mice from LPS-induced and sepsis-induced acute lung injury (ALI) mouse models.
A5S is a MyD88 inhibitor of not affecting the expression of IFN-β in acquired immunity in suppressing excessive inflammatory response.

物理化学性质&存储条件

分子量	444.37
分子式	C22H26BrN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(4-((1H-Indol-2-yl)methyl)piperazin-1-yl)-3-(4-bromophenoxy)propan-2-ol

参考文献

1. Pan Chen, et al. Journal of Medicinal Chemistry. December 7, 2024