MyD88 inhibitor 15d

Chemical Structure : MyD88 inhibitor 15d

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货号: PC-21179Not For Human Use, Lab Use Only.

MyD88 inhibitor 15d is a potent, small molecule inhibitor of MyD88 homodimerization, dose-dependently inhibits LPS-induced IL-6 and TNF-α in macrophages with IC50 of 2.52 and 0.89 uM, respectively.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

MyD88 inhibitor 15d is a potent, small molecule inhibitor of MyD88 homodimerization, dose-dependently inhibits LPS-induced IL-6 and TNF-α in macrophages with IC50 of 2.52 and 0.89 uM, respectively.
MyD88 inhibitor 15d prevents LPS-induced activation of MAPK and NF-κB signaling pathways.
MyD88 inhibitor 15d (10 mg/kg) protects against LPS-induced acute lung injury in mice, protects against pulmonary inflammation on histopathological changes in lung tissues of mice challenged with LPS.

物理化学性质&存储条件

分子量	497.57
分子式	C24H27N5O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(4-hydroxy-3-methoxyphenyl)thiazol-2-yl)-3-(4-(3-nitrobenzyl)piperazin-1-yl)propanamide

参考文献

1. Lingfeng Chen, et al. Eur J Med Chem. 2019 Jan 1;161:22-38.