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首页-小分子抑制剂&激动剂-GPCR-Lysophospholipid Receptor-Mocravimod
Mocravimod

Chemical Structure : Mocravimod

CAS No.: 509092-16-4

Mocravimod (KRP-203, KRP203)

货号: PC-60049Not For Human Use, Lab Use Only.

Mocravimod (KRP203) is a synthetic immunosuppressant that functions as a S1P1 receptor agonist.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Mocravimod (KRP203) is a synthetic immunosuppressant that functions as a S1P1 receptor agonist.
    Mocravimod (KRP203) significantly inhibits infiltration of inflammatory cells, expression of endothelin-1 and TGF-beta1, and IgG deposition and eventually attenuates neointimal formation and myocardial fibrosis.
    Mocravimod (KRP203) prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts.

    物理化学性质&存储条件

    分子量 443.986
    分子式 C24H26ClNO3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-Amino-2-(2-(2-chloro-4-(3-benzyloxyphenylthio)phenyl)ethyl)-1,3-propanediol

    参考文献

    1. Shimizu H, et al. Circulation. 2005 Jan 18;111(2):222-9.

    2. Takahashi M, et al. Transplant Proc. 2005 Jan-Feb;37(1):143-5.

    3. Suzuki C, et al. J Heart Lung Transplant. 2006 Mar;25(3):302-9.

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