Meayamycin

Chemical Structure : Meayamycin

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货号: PC-62419Not For Human Use, Lab Use Only.

Meayamycin is an analogue of FR901464 that binds to the splicing factor 3b (SF3b) complex and inhibits pre-mRNA splicing, shows picomolar antiproliferative activity against various cancer cell lines and multidrug-resistant cells.

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生物&药学活性

Meayamycin is an analogue of FR901464 that binds to the splicing factor 3b (SF3b) complex and inhibits pre-mRNA splicing, shows picomolar antiproliferative activity against various cancer cell lines and multidrug-resistant cells.

物理化学性质&存储条件

分子量	505.652
分子式	C28H43NO7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2Z,4S)-4-(Acetyloxy)-N-[(2R,3R,5S,6S)-tetrahydro-6-[(2E,4E)-5-[(3R,4R,5R)-4-hydroxy-7,7-dimethyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methyl-2,4-pentadien-1-yl]-2,5-dimethyl-2H-pyran-3-yl]-2-pentenamide

参考文献

1. Albert BJ, et al. Mol Cancer Ther. 2009 Aug;8(8):2308-18.

2. Visconte V, et al. Blood. 2012 Oct 18;120(16):3173-86.

3. Albert BJ, et al. J Am Chem Soc. 2007 Mar 7;129(9):2648-59.

Meayamycin

生物&药学活性

物理化学性质&存储条件

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Meayamycin

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物理化学性质&存储条件

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