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首页-小分子抑制剂&激动剂-Immunology/Inflammation-STING-MSA-2
MSA-2

Chemical Structure : MSA-2

CAS No.: 129425-81-6

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MSA-2 (MSA2)

货号: PC-73371Not For Human Use, Lab Use Only.

MSA-2 is a potent and orally available non-nucleotide STING agonist with EC50 of 8.3 and 24 uM for human STING isoforms WT and HAQ, respectively.

规格 价格 库存 数量
5 mg ￥1980 In stock
10 mg ￥2980 In stock
25 mg ￥4980 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MSA-2 is a potent and orally available non-nucleotide STING agonist with EC50 of 8.3 and 24 uM for human STING isoforms WT and HAQ, respectively.
MSA-2 exhibits antitumor activity and stimulates interferon-β secretion in tumors.
MSA-2 induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models.

物理化学性质&存储条件

分子量 294.32
分子式 C14H14O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(5,6-Dimethoxybenzo[b]thiophen-2-yl)-4-oxobutanoic acid

参考文献

1. Bo-Sheng Pan, et al. Science. 2020 Aug 21;369(6506):eaba6098.

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